Intra-articular treatment with triamcinolone acetonide-loaded liposomes in the rat high-fat diet groove model

Authors
NM Korthagen, HM de Visser, G Geusebroek, G Storm et al

Lab
Utrecht Univ., Utrecht, Netherlands

Journal
Osteoarthritis and Cartilage

Abstract
Local intra-articular injections with triamcinolone acetonide (TA) is favorable as an anti-inflammatory treatment. In animal (rat) models of OA it was shown that TA can reduce osteophyte formation and thus may be beneficial as a disease modifying treatment. To evaluate the potential for slow-release anti-inflammatory treatment in a model mimicking metabolically accelerated post-traumatic OA, we evaluated the effect of TA-loaded liposomes, in the high-fat diet groove model in rats.

BIOSEB Instruments Used:
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)