Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice

Authors
BA Hain, H Xu, DL Waning 

Lab
Dept. of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, PA, USA

Journal
Journal of Cachexia, Sarcopenia and Muscle

Abstract
Chemotherapy is an essential treatment to combat solid tumours and mitigate metastasis. Chemotherapy causes side effects including muscle wasting and weakness. Regulated in Development and DNADamage Response 1 (REDD1) is a stress-response protein that represses the mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1), and its expression is increased in models of muscle wasting. The aim of this study was to determine if deletion of REDD1 is sufficient to attenuate chemotherapy-induced muscle wasting and weakness in mice.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)