Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopathy

Authors
SE Moser, AM Brown, BC Clark

Lab
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA

Journal
Alcoholism: Clinical and Experimental Research

Abstract
Weakness is a common clinical symptom reported in individuals with chronic alcohol use disorder. However, it remains unclear whether low strength in these individuals is directly related to excessive ethanol intake, other deleterious factors (lifestyle, environment, genetics, etc.), or a combination of both. Therefore, we examined whether (and how) ethanol reduces the muscle’s force-producing capacity using a controlled in vivo preclinical mouse model of excessive ethanol intake.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)