Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1 and R1 signaling
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I Cho, JM Kim, EJ Kim et al

Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea

Journal of Neuroinflammation

Postoperative pain is a common phenomenon after surgery and is closely associated with the development of postoperative cognitive dysfunction (POCD). Persistent pain and systemic inflammation caused by surgery have been suggested as key factors for the development of POCD. Fractalkine (CX3CL1) and its receptor, the CX3C chemokine receptor 1 (CX3CR1), are known to play a key role in pain and inflammation signaling pathways. Recent studies have shown that the regulation of CX3CR1/L1 signaling influences the development of various diseases including neuronal diseases. We determined whether CX3CR1/L1 signaling is a putative therapeutic target for POCD in a mouse model.

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