RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication- reducing pain and inflammation in gouty arthritis in mice
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- Catégories : Arthrite & Arthrose , Publications - ID: 1547

TH Zaninelli, V Fattori, T Saraiva‐SantoS

Universidade Estadual de Londrina, Londrina, ParanA, Brazil

British Journal of Pharmacology

Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain. Current therapies are often ineffective in reducing gout-related pain. Resolvin D1 (RvD1) is a specialized pro-resolving lipid mediator with anti-inflammatory and analgesic proprieties. In this study, we evaluated the effects and mechanisms of action of RvD1 in an experimental mouse model of gouty arthritis, an aim that was not pursued previously in the literature.

BIOSEB Instruments Used:
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

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