Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation-

Authors
M. Dumont, C. Strazielle, M. Staufenbiel, R. Lalonde.

Lab
Université de Rouen, INSERM U614, IFRMP23, Faculté de Médecine et de Pharmacie, Rouen, France ; CHUM/St-Luc, Centre de Recherche en Sciences Neurologiques, Montréal, Canada.

Journal
Brain Research

Abstract
Transgenic mice overexpressing the _APP gene with the Swedish mutation under the control of the murine thy1 promoter show Alzheimer-like characteristics such as A_ plaques in cerebral cortex and vessel walls. By comparison to age-matched non-transgenic controls, 2-year-old female APP23 transgenic mice crossed more segments in the open-field and had a higher number of fast ambulatory and stereotyped movements in a photocell activity chamber. In addition, APP23 mice entered more often and spent more time in the open arms of the elevated plus-maze. The acquisition of place learning in the Morris water maze was impaired in APP23 transgenic mice, but not in probe and visible platform subtasks. These results indicate that hyperactivity and impaired learning abilities characterize this mouse model of Alzheimer's disease and cerebral angiopathy.

BIOSEB Instruments Used:
Acquisition software: ACTITRACK (ACTITRACK),Infrared Actimeter (LE8815)