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Algomètre à pince instrumentée pour rongeurs - Sans fil
Référence : BIO-RP-WRS
Catégorie : Douleur - Allodynie/Hyperalgésie Mécanique
Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!
Présentation
L’Algomètre à Pince Instrumentée pour Rongeurs de Bioseb permet, à l’aide d’un forceps calibré, d’induire une stimulation mécanique quantifiable sur un animal (rat ou souris) sur une échelle linéaire. Le protocole optimal a été défini expérimentalement en déterminant les effets de 3 meures répétitives sur les 2 pattes arrières, respectivement sur le long terme (9 jours), le moyen terme (1 jour) et le court terme (2 heures). Cet instrument a été développé à l’origine en tant qu’algésimètre/algomètre (instrument de mesure de l’analgésie, ou analgésimètre) pour les tests nociceptifs. Pour cet usage spécifique, il constitue une alternative au test de “RANDALL & SELITTO” - mais présente les avantages suivants comparé au test classique :
• Manipulation plus éthique, moins stressante pour l’animal (rat ou souris), résultant en des mesures moins variables
• Mesures plus rapides, moins traumatisantes pour les tissus
• Mesure digitalisée avec traçabilité métrologique
Cependant, cet algésimètre basé sur une pince peut également être utilisé pour d’autres applications nécessitant une valeur de force ou de pression contrôlée, comme par exemple :
• Récupération sensitive après l’écrasement d’un nerf: le pincement est appliqué en différents endroits de la patte pour vérifier la récupération sensitive
• Blessures mécaniques pour les modèles thrombotiques
• Stimulation mécanique pour les enregistrements électrophysiologiques in-vivo utilisant les possibilités de déclenchement de l’enregistrement par seuil de force
Des études comparatives (incluant des tests comparatifs avec l’algésimètre de Randall & Sellito) ont démontré la précision de cet algésimètre à pince pour des mesures rapides, simples et reproductibles du seuil de douleur mécanique des membres de rat. De plus, l'algomètre à pince instrumentée permet de de procéder à des tests analgésiques sur rat avaec un niveau de contrainte minimum, réduisant la variabilité des données.
L’un de ces travaux de recherche expérimentale a été effectué par l’équipe du Prof. Poisbeau au département de 'Nociception & Douleur' de 'l’Institut des Neurosciences Cellulaires et Intégratives' (Université Louis pasteur) de Strasbourg.
Ces travaux ont été décrits dans 2 articles publiés dans des revues scientifiques internationales à comité de lecture :
• Méthode de validation :
Calibrated Forceps: A Sensitive and Reliable Tool for Pain and Analgesia Studies, by Luis-Delgado et al. in The Journal of pain, Décembre 2005
• Travail scientifique :
Inflammatory Pain Upregulates Spinal Inhibition via Endogenous Neurosteroid Production, by P. Poisbeau et al. in The Journal of neuroscience, Décembre 2005
Cliquez sur le titre de l’un de ces articles pour envoyer une demande de téléchargement du fichier PDF
NOUVEAU: Sans fil
Une gamme complète d'instruments Bioseb, incluant la pince instrumentée, comprend désormais notre nouvelle technologie sans fil: grâce au boîtier sans fi placé sur le poignet de l'opérateur, il n'y a plus de câble entre la console éléctronique de l'écran et les capteurs
Cette nouvelle technologie sans fil offre de nombreux avantages:
• Mailleure liberté de mouvement: plus de câbes agaçants !
• Une configuration flexible pour votre laboratoire : concevez votre espace de travail sans limites
• Libérez vous des contraintes physiques : concentrez vous sur votre expérience !
Fourni avec: Composants inclus
Ces composants intégrés facilitent les mesures analgésiques:
• Bâti de bureau pour une lecture facile
• Pédale pour le tarage “main libre” de l’analgésimètre à pince pour rongeurs au démarrage
• Sortie RS232 pour le transfert des données à un PC
• Notre nouveau design de pince permet le montage d’embouts personnalisés pour répondre à vos applications analgésiques les plus spécifiques. Merci de nous contacter si vous avez une requête spéciale concernant la pince, et nous ferons de notre mieux pour la satisfaire.
L'algomètre à pince instrumentée pour rongeurs de Bioseb est founi avec : unité de contrôle électronique (avec batteries et adaptateur secteur) ; une pince pour rat ou souris d’une capacité de 2000 grammes ; une mallette de transport ; une pédale pour tarage de la force “main-libre” ; une sortie RS232 ; un manuel d’utilisationOptions
• Notre logiciel Bio-CIS2 en option (pour Windows) envoit les valeurs affichées directement dans une feuille de calculs Excel. Cela permet d’obtenir immédiatement un rapport pour analyse supplémentaire, sans erreurs de recopie. Fourni avec un câble RS-232.
• Module externe pour allumer une diode rouge ou émettre un son lorsqu’un seuil de force prédéfini a été atteint.
• Sortie analogique et câble.
• Sortie TTL
• Tests et capteurs aditionnels : notre sonde de Test de Von Frey Electronique et notre Algomètre pour Petit Animal sont fournis avec leurs propres modules de calibration qui sont reconnus par l’unité élecronique de la Pince Instrumentée.Nouveau système AlgoKit
AlgoKit
UN ENSEMBLE COMPLET POUR REPONDRE
A TOUTES LES SITUATIONS DE MESURE DE LA DOULEUR CHEZ LES RONGEURS:
SONDES MULTIPLES, BOÎTIER DE CONTRÔLE ET LOGICIEL UNIQUES
A TOUTES LES SITUATIONS DE MESURE DE LA DOULEUR CHEZ LES RONGEURS:
SONDES MULTIPLES, BOÎTIER DE CONTRÔLE ET LOGICIEL UNIQUES
Vous pouvez également être intéressé par notre nouveau système ALGOKIT afin d'étendre le champs des possibles pour vos recherches. Pour répondre aux diverses demandes concernant les différents cas possibles en mesure de la douleur et pour faire face à toutes les situations, Bioseb est fière de présenter l'AlgoKit construit autour de notre test d'Incapacitance Statique (SWB: Distribution Pondérale Statique), avec son écran tactile couleurs, et de jusqu'à 3 capteurs additionnels parmi notreVon Frey Électronique, de la Pince Instrumentée et de l'algomètre pour petits animaux (SMALGO) combinés à un unique boitier de contrôle ! .
Avantages:
• Flexibilité : solution complète pour les mesure d’analgésie à portée de main !
• Compatible avec le logiciel d'acquisition BIO-CIS2 pour améliorer la répétabilité des tests nociceptifs.
BIO-RP-WRS
Fiche technique
- Sortie de données
- RS232 pour PC
- Nombre d'animaux
- Rat ou souris individuellement (2 pinces différentes)
- Alimentation
- Sur batterie, instrument autonome Possibilité d'alimentation via un adaptateur secteur 220V/110V 50hz/60hz
- Plage
- De 0 à 2 000 grammes (modèle pour rat)
- Résolution
- 0.1 gramme ou 0,001N
- Applications
- Arthrite & Arthrose
Douleur
Système Nerveux Central (SNC)
Système sensoriel
Thématiques transversales
Troubles de l'humeur
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[title] => PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain
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[title] => The Contribution of TSLP Activation to Hyperalgesia in Dorsal Root Ganglia Neurons of a Rat
[paragraph_crop] => The Contribution of TSLP Activation to Hyperalgesia in Dorsal Root Ganglia Neurons of a Rat
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[title] => In VivoÊCalcium Imaging Visualizes Incision-Induced Primary Afferent Sensitization and Its Amelioration by Capsaicin Pretreatment
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[1402] => Array
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[id] => 1402
[url] => https://bioseb.com/fr/news/linalool-odorinduced-analgesia-is-triggered-by-trpa1-independent-pathway-in-mice-n1402
[title] => Linalool odor_induced analgesia is triggered by TRPA1-independent pathway in mice
[paragraph_crop] => Linalool odor_induced analgesia is triggered by TRPA1-independent pathway in mice
[image_presente] =>
[date] => 2021-04-26 00:00:00
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[link_rewrite] => Systeme-somatosensoriel
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[url] => https://bioseb.com/fr/news/methylmercury-induces-hyperalgesia-and-allodynia-through-spinal-cord-dorsal-horn-neuronal-activation-and-subsequent-somatosensory-cortical-circuit-formation-in-rats-n1398
[title] => Methylmercury induces hyperalgesia and allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats
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[image_presente] =>
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[1392] => Array
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[id] => 1392
[url] => https://bioseb.com/fr/news/impact-of-hepatoma-derived-growth-factor-blockade-on-resiniferatoxin-induced-neuropathy-n1392
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[paragraph_crop] => Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy
[image_presente] =>
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[1360] => Array
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[id] => 1360
[url] => https://bioseb.com/fr/news/anti-inflammatory-and-analgesic-effects-of-trpv1-polypeptide-modulator-aphc3-in-models-of-osteo-and-rheumatoid-arthritis-n1360
[title] => Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of Osteo-and Rheumatoid Arthritis
[paragraph_crop] => Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of [...]
[image_presente] =>
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[1369] => Array
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[id] => 1369
[url] => https://bioseb.com/fr/news/overexpression-of-chloride-importer-nkcc1-contributes-to-the-sensory-affective-and-sociability-phenotype-of-rats-following-neonatal-maternal-separation-n1369
[title] => Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation
[paragraph_crop] => Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability [...]
[image_presente] =>
[date] => 2020-12-11 00:00:00
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[title] => EFFECT OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID- BIS-2-PYRIDYL-1-2-4-TRIAZOLYL-3-PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS PYRIDYL-1-2-4-TRIAZOLYL-3-PROPANE AND THEIR ADDUCT ON THE PAIN SENSITIVITY OF RATS
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[title] => Effect of 1-Hydroxy-1-1-thylidendiphosphone Acid- Bis-2-Pyridyl-1-2-4-Triazolyl-3-Propane and their adduct on the pain sensitivty of Rats
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[title] => INFLUENCE OF 1-HYDROXY-1-1-ETHYLIDENDIPHOSPHONE ACID AND BIS -2-PYRIDYL-1-2-4-TRIAZOLYL-3- PROPANE ON PAIN SENSITIVITY OF RAT FEMALES
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[title] => Cholecalciferol -Vitamin D 3- Reduces Rat Neuropathic Pain by Modulating Opioid Signaling
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[title] => Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA and ROCK Associated with CRMP2 Phosphorylation
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[title] => Application of calibrated forceps for assessing mechanical nociception with high time resolution in mice
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[title] => A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing
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[title] => Pharmacodynamic Evaluation of Sustained Release of PEG and PLA Formulation Including Bupivacaïne or Ropivacaïne versus 0-25% Bupivacaïne After Sciatic Nerve Block in Rat
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[title] => Long-Term Behavioral Effects in a Rat Model of Prolonged Postnatal Morphine Exposure-
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[url] => https://bioseb.com/fr/news/en3427--a-novel-cationic-aminoindane-with-long-acting-local-anesthetic-properties-n805
[title] => EN3427- A Novel Cationic Aminoindane with Long-Acting Local Anesthetic Properties
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[title] => Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons
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[title] => Characterization of the fast GABAergic inhibitory action of etifoxine during spinal nociceptive processing in male rats
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[title] => Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130-
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[title] => Plasma glucocorticoids differentially modulate phasic and tonic GABA inhibition during early postnatal development in rat spinal lamina II
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[title] => Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs
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[date] => 2013-10-28 00:00:00
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[title] => Long-Lasting Spinal Oxytocin Analgesia Is Ensured by the Stimulation of Allopregnanolone Synthesis Which Potentiates GABAA Receptor-Mediated Synaptic Inhibition
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[title] => Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy
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[title] => Long-Term Changes in Trigeminal Ganglionic and Thalamic Neuronal Activities following Inferior Alveolar Nerve Transection in Behaving Rats
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[date] => 2012-06-18 00:00:00
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[title] => Erythropoietin Restores C-Fiber Function and Prevents Pressure Ulcer Formation in Diabetic Mice-
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[title] => Endogenous Opioids Released During Non-Nociceptive Environmental Stress Induce Latent Pain Sensitization Via a NMDA-Dependent Process-
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[title] => Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants- prediction for efficacy in animal models of neuropathic pain?
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[title] => The rat intervertebral disk degeneration pain model- relationships between biological and structural alterations and pain-
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[date] => 2011-05-30 00:00:00
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[title] => Phosphorylation of spinal N-methyl-d-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful neuropathy-
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[title] => Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain-
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[title] => Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus infraorbital nerve-ligated rats – Behavioral- pharmacological and immunohistochemical investigations-
[paragraph_crop] => Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus [...]
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[title] => Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3_-reduced neurosteroids-
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[url] => https://bioseb.com/fr/news/increase-in-morphine-antinociceptive-activity-by-a-p-glycoprotein-inhibitor-in-cisplatin-induced-neuropathy--n241
[title] => Increase in morphine antinociceptive activity by a P-glycoprotein inhibitor in cisplatin-induced neuropathy-
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[date] => 2009-11-06 00:00:00
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[url] => https://bioseb.com/fr/news/combination-of-microsurgery-and-gene-therapy-for-spinal-dorsal-root-injury-repair--n199
[title] => Combination of Microsurgery and Gene Therapy for Spinal Dorsal Root Injury Repair-
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[image_presente] =>
[date] => 2009-06-30 00:00:00
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[title] => Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms-
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[date] => 2008-10-31 00:00:00
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[title] => Specific Antinociceptive Activity of Cholest-4-en-3-one- Oxime -TRO19622- in Experimental Models of Painful Diabetic and Chemotherapy-Induced Neuropathy-
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[title] => Mechanical- thermal and formalin-induced nociception is differentially altered in 5-HT1A_ and _- 5-HT1B_ and _- 5-HT2A_ and _- 5-HT3A_ and _ and 5-HTT_ and _ knock-out male mice-
[paragraph_crop] => Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A_/_, [...]
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[date] => 2007-08-30 00:00:00
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[url] => https://bioseb.com/fr/news/antinociceptive-efficacy-of-lacosamide-in-rat-models-for-tumor--and-chemotherapy-induced-cancer-pain--n117
[title] => Antinociceptive efficacy of lacosamide in rat models for tumor- and chemotherapy-induced cancer pain-
[paragraph_crop] => Antinociceptive efficacy of lacosamide in rat models for tumor- and chemotherapy-induced [...]
[image_presente] =>
[date] => 2007-06-22 00:00:00
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[url] => https://bioseb.com/fr/news/agmatine-induces-antihyperalgesic-effects-in-diabetic-rats-and-a-superadditive-interaction-with-r---3--2-carboxypiperazine-4-yl--propyl-1-phosphonic-acid--a-n-methyl-d-aspartate-receptor-antagonist--n116
[title] => Agmatine Induces Antihyperalgesic Effects in Diabetic Rats and a Superadditive Interaction with R-–--3--2-Carboxypiperazine-4-yl--propyl-1-phosphonic Acid- a N-Methyl-d-aspartate-Receptor Antagonist-
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[url] => https://bioseb.com/fr/news/lacosamide--a-review-of-preclinical-properties--n106
[title] => Lacosamide- A Review of Preclinical Properties-
[paragraph_crop] => Lacosamide: A Review of Preclinical Properties.
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[date] => 2007-03-30 00:00:00
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[url] => https://bioseb.com/fr/news/the-transcription-factor-fosb-is-recruited-by-inflammatory-pain--n83
[title] => The transcription factor _FosB is recruited by inflammatory pain-
[paragraph_crop] => The transcription factor _FosB is recruited by inflammatory pain.
[image_presente] =>
[date] => 2006-09-30 00:00:00
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[url] => https://bioseb.com/fr/news/antinociceptive-efficacy-of-lacosamide-in-a-rat-model-for-painful-diabetic-neuropathy--n79
[title] => Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy-
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[date] => 2006-06-06 00:00:00
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[id] => 70
[url] => https://bioseb.com/fr/news/calibrated-forceps--a-sensitive-and-reliable-tool-for-pain-and-analgesia-studies--n70
[title] => Calibrated Forceps- A Sensitive and Reliable Tool for Pain and Analgesia Studies-
[paragraph_crop] => Calibrated Forceps: A Sensitive and Reliable Tool for Pain and Analgesia Studies.
[image_presente] =>
[date] => 2006-01-30 00:00:00
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[url] => https://bioseb.com/fr/news/inflammatory-pain-upregulates-spinal-inhibition-via-endogenous-neurosteroid-production--n62
[title] => Inflammatory Pain Upregulates Spinal Inhibition via Endogenous Neurosteroid Production-
[paragraph_crop] => Inflammatory Pain Upregulates Spinal Inhibition via Endogenous Neurosteroid Production.
[image_presente] =>
[date] => 2005-12-14 00:00:00
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[title] => Douleurs inflammatoires
[link_rewrite] => Douleurs-inflammatoires
)
[48] => Array
(
[id_prestablog_categorie] => 48
[title] => Perception du chaud et du froid
[link_rewrite] => Perception-du-chaud-et-du-froid
)
[2] => Array
(
[id_prestablog_categorie] => 2
[title] => Publications
[link_rewrite] => publications
)
[13] => Array
(
[id_prestablog_categorie] => 13
[title] => Système sensoriel
[link_rewrite] => Systeme-sensoriel
)
)
)
)
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Algomètre à pince instrumentée pour rongeurs - Sans fil
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