Amelioration of muscle wasting by glucagon_like peptide_1 receptor agonist in muscle atrophy

Authors
Y Hong, JH Lee, KW Jeong, CS Choi, HS Jun

Lab
College of Pharmacy, Gachon University, 7 45 Songdo-dong, Yeonsu-ku, Incheon, 406 840 , Korea

Journal
Journal of Cachexia, Sarcopenia and Muscle

Abstract
Skeletal muscle atrophy is deÞned as a reduction of muscle mass caused by excessive protein degradation. However, the development of therapeutic interventions is still in an early stage. Although glucagon-like peptide-1 receptor (GLP1R) agonists, such as exendin-4 (Ex-4) and dulaglutide, are widely used for the treatment of diabetes, their effects on muscle pathology are unknown. In this study, we investigated the therapeutic potential of GLP-1R agonist for muscle wasting and the mechanisms involved.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)