Paeonia lactiflora extract suppresses cisplatin-induced muscle wasting via downregulation of muscle-specific ubiquitin E3 ligases- NF-kappaB signaling- and cytokine levels

Authors
J Jang, H Lee, J Song et al

Lab
Chung-Ang University College of Medicine, Seoul, Republic of Korea

Journal
Journal of Ethnopharmacology

Abstract
Cisplatin is a broad-spectrum anticancer drug used in diverse types of cancer. However, muscle wasting is a common side effect of cisplatin chemotherapy. This study aimed to elucidate the effects of an ethanol extract of the root of Paeonia lactiflora Pall. (Radix Paeoniae, RP) on cisplatin-induced muscle wasting along with its molecular mechanism.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)