EN3427- A Novel Cationic Aminoindane with Long-Acting Local Anesthetic Properties

Authors
Banerjee M, Baranwal A, Saha S, Saha A, Priestley T

Lab
TCG LifeSciences, Kolkata, India and TCG LifeSciences, New York, New York

Journal
Anesth Analg.

Abstract
Currently approved local anesthetic drugs provide relatively brief local anesthesia that is appropriate and even desirable in some settings, but an extended duration of action beyond their capabilities would be a distinct benefit in other clinical situations. We implemented a drug discovery program that sought to identify novel local anesthetic molecules that specifically demonstrated a long-acting, preferential action on nociceptor sensory afferents that expressed transient receptor potential (TRP) channels. The hypothesis we tested was whether relatively membrane-impermeant local anesthetic molecules could confer long-lasting anesthesia if neuronal access was facilitated by TRP channel activation. The current work describes in vivo studies on a lead molecule that emerged from the discovery program, EN3427, in several rodent pain models.

BIOSEB Instruments Used:
Rodent pincher - analgesia meter (BIO-RP-M)