Arthritis sensory and motor scale- predicting functional deficits from the clinical score in collagen-induced arthritis

Authors
AL Mausset-Bonnefont, M Cren, R Vicente, J Quentin

Lab
IRMB, University of Montpellier, INSERM, Montpellier, France

Journal
Arthritis Research & Therapy

Abstract
In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we extensively quantified sensory and motor deficits in CIA mice during natural disease progression and therapeutic treatment. Then, we used these data to build a scale to predict functional deficits on the basis of the classical clinical score.

BIOSEB Instruments Used:
Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M),Infrared Actimeter (LE8815)