Induction of brain Nrf2-HO-1 pathway and antinociception after different physical training paradigms in mice
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- Catégories : Douleur , Douleurs générales , Publications - ID: 1050

Authors
AbdulkarimTutakhailaQand AghaNazarybDelilaLebsiraSaadiaKerdine-RomercFranoisCoudore


Lab
CESP/National Institute of Health and Medical Research INSERM UMR-S 1178, Paris-Sud University, Faculty of Pharmacy, Paris-Saclay University, France

Journal
Life Sciences

Abstract
Aim Activation of the Nrf2-antioxidant response element signaling pathway is a major mechanism in the cellular defense against oxidative or electrophilic stress through conjugative reactions and by enhancing cellular antioxidant capacity. Although exercise training up-regulates antioxidant defenses system, while information regarding the intensity levels of physical exercise that acts on the cellular protection systems is limited.
Main methodsKey findings This study confirmed that only vigorous and longer duration aerobic exercise increased Nrf2 protein level in the hippocampus and HO-1 protein level in the cortex and reduced pain perception. Mechanical and thermal hypoalgesia were only observed in exercise groups after 7_weeks of physical training.
Significance The overall findings in this study confirm that only the long duration intensive forced exercise reduced inflammatory pain by induction of Nrf2/HO-1 antioxidant signaling pathway.

BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP)

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