Protective effects of Liuwei dihuang water extracts on diabetic muscle atrophy

Authors
YT Tseng, WH Chang, CC Lin, FR Chang, PC Wu

Lab
College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Journal
Phytomedicine

Abstract
In C2C12 myotubes, LWDH-WE attenuated MG-induced cellular death and oxidative damage accompanied with improving mitochondrial membrane potential, inhibiting NADPH oxidase (Nox) activation, and ROS production. Moreover, LWDH-WE could attenuate MG-induced atrophy of C2C12 myotubes accompanied with regulating protein synthesis (IGF-1R, Akt, mTOR) and protein degradation (FoxO3a, atrogin-1, MuRF-1) signals. In STZ-induced diabetic mice, LWDH-WE improved body weight and skeletal muscle mass of mice. LWDH-WE also enhanced muscle strength of STZ-induced diabetic mice. Furthermore, LWDH-WE enhanced the improvement of insulin on gastrocnemius muscle mass and grip strength in STZ-treated mice.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)