The Therapeutic Effect of iMSC-Derived Small Extracellular Vesicles on Tendinopathy Related Pain Through Alleviating Inflammation- An in vivo and in vitro Study

Authors
Z Zhu, R Gao, T Ye, et al

Lab
Shanghai Jiao Tong University Affiliated Sixth PeopleÕs Hospital, Shanghai, PeopleÕs Republic of China

Journal
Journal of Inflammation

Abstract
Tendinopathy is a common cause of tendon pain. However, there is a lack of effective therapies for managing tendinopathy pain, despite the pain being the most common complaint of patients. This study aimed to evaluate the therapeutic effect of small extracellular vesicles released from induced pluripotent stem cell-derived mesenchymal stem cells (iMSC-sEVs) on tendinopathy pain and explore the underlying mechanisms.

BIOSEB Instruments Used:
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5),Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M)